Review Article

Health Benefits of Mango (Mangiferaindica L) and Mangiferin

Anand Swaroop1, Manashi Bagchi1,Hiroyoshi Moriyama1,2and DebasisBagchi*1,3

1. Cepham Research Center, Somerset, NJ 08854, USA
2. The Japanese Institute for Health Food Standards, Bunkyo-ku, Tokyo, Japan 113-0033
3. Departments of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, USA
*Corresponding Author: DebasisBagchi, Ph.D., MACN, CNS, MAIChEDepartment of Pharmacological and Pharmaceutical Sciences,University of Houston College of PharmacyHouston, TX 77204, USA, Telephone: 925 948 6951; E-mail:


Mango (MangiferaIndica Linn.) fruit is very popular around the world, which provides a soothing sweet aroma and delicious taste, while mango leaves are becoming increasingly popular for its battery of therapeutic benefits including the treatment of diabetes, blood pressure, restlessness, respiratory problems, gall bladder and kidney stones, dysentery, ear aches, diverse inflammatory responses, wound-healing, heat stroke, cardiovascular problems, diverse gastrointestinal health, regularity and digestion. Mango fruits, pulp and leaves are integral parts of Asian culinary purpose. Especially, raw mangoes are used in salads and pickles, while ripe mangoes are consumed as fruits, milkshakes and desserts. Literature reveals that mango fruits, fruit pulp and leaf have been used for multiple health problems and ailments especially for digestive and gastrointestinal health in Ayurvedic medicinesfor thousands of years. Chemical investigations have demonstrated that mango and mango leaves contain structurally diverse polyphenolicantioxidants and micronutrients including mangiferin, beta-carotene, lutein, zeaxanthin, riboflavin, thiamine, niacin, anthocyanins and anthocyanidins, flavonoids, alkaloids and minerals. This review provides an overview and highlights on mangiferin and mango leaf extract on multiple health benefits in human health and disease prevention.

Key words: MangiferaIndica Linn: fruit and leaves, mangiferin, antioxidant; anti-inflammatory, anti-diabetic; gastro-intestinal and gut health, regularity


Literature reveals that mango [MangiferaIndica Linn (family Anacardiaceae)], a popular tropical fruit, originated from the Indian sub-continent and then started becoming popular around the World. Around fifth and fourth centuries BC, cultivation of mango started in Southeast Asia, and then in East and West Africa around 10th century AD, and finally in Brazil, Mexico, Spain, Canary Islands and Portugal,West Indies and Caribbean Islands[1-7]. Today, India, China, Thailand and Mexico are the largest producers and exporters of mango[1,3].

Mango trees, flowers, fruits, seeds, leaves and bark have been reported to exhibit diverse medicinal properties and health benefits. Scientific literature demonstrates thatdifferent parts of mango tree and its integral constituents exhibit a number of health benefits including the reduction of chronic inflammatory conditions, anti-viral and anti-bacterial effects, immunomodulatory, anti-spasmodic, gastrointestinal well-being as well as metabolically-mediated chronic diseases[3-5].

Chemical Constituents

Mango contains 15% carbohydrates, 1.6% dietary fiber, 0.38% fat and 0.82% protein[5,8]. HPLC equipped with diode array and mass spectrometric detection, HPLC/atmospheric pressure chemical ionization mass spectrometry (HPLC/APcI-MS), atmospheric pressure chemical ionization-time-of-flight mass spectrometry [LC-(APcI (+))-MS] and HPTLC techniques have been extensively used for the detection of these structurally diverse constituents[9-11].
Mango fruit, seed, leaves, bark and roots have diverse phytochemical constituents including polyphenolic antioxidants including flavonoids, triterpenoids, micronutrients[5,8], as follows:Flavor of mango fruits contain volatile organic molecules including terpenes, furanones, lactones and esters. Mango leaves contains multiple minerals, vitamins including calcium, magnesium, potassium, sodium, zinc, cadmium, copper and phosphorous, vitamins C, B1,B2 and B4, polyphenolicxanthonoids, mangiferin, selected anthocyanidins including delphinidin, peonidin and cyanidin, leucoanthocyanins, catechin and gallic tannins[5,8].Mango leaf oil contains sesquiterpenes, mangiferin, δ-3-carene, α-gurjunene, β-selinene and β-caryophyllene. Mango leaf has been demonstrated to contain mangiferin, selected anthocyanidins including delphinidin, peonidin and cyanidin, leucoanthocyanins, catechin and gallic tannins. Mango leaves and flowers also contain essential oils[5,8]. The flower also contains a series of gallic acid derivatives, while the roots contain chromone derivatives. Mango fruit pulp contains vitamins A, C, b-carotene, xanthophylls and cis-9 and cis-15-octadecadienoic. Phenolic antioxidants including protocatechuic acid, catechin, gama-aminobutyric acid (GABA), kinic acid, shikimic acid, as well as tetracyclic triterpenoids, Indicoside A and B, manghopanal, mangoleanone, friedelin, cycloartan-3b-30-diol and derivatives, mangsterol, manglupenone, mangocoumarin, mangiferolic acid derivatives, carbohydrates and polyols were isolated from mango stem bark[5,8].

The natural C-glucosidexanthone,mangiferin, chemically known as 2-C-β-D-glucotyranosyl-1,3,6,7-tetrahydroxyxanthen-9-one CAS 4773-96-0(Formula C19H18O11; Molecular Weight: 422.35; melting point 271°C) (Figure 1). As indicated earlier, mangiferin is abundant in the mango leaves, fruits, stem bark, heartwoods and roots[2-4]. Mangiferin, a light yellow color crystalline powder, is slightly soluble in ethanol, sparingly soluble in methanol and water and practically insoluble in diethyl ether, acetone, and n-hexane[12].Mangiferin is a novel antioxidant and exhibit pro-hypoglycemic activity by modulating glucose metabolism, ameliorating insulin resistance, lowering cholesterol synthesis, and inhibiting the expression of the TNFa and inducible nitric oxide synthase[2-5,13].

The acute oral toxicity of mango leaf extract was found to be greater than 5,000 mg/kg body weight p.o. Both gross anatomy check and macroscopic evaluation were conducted and no signs of gross toxicity were observed till 14 days of treatment. Another study demonstrated no signs of gross or organ toxicity up to 18.4 gms mango leaf extract/kg bodyweight p.o. In another independent sub-chronic, repeated dose sub-chronic toxicity study using either 0, 100-, 300- or 900 mg mango leaf extract/kg body weight p.o. doses over a period of 90-consecutive days using exhibited no signs of toxic manifestations were observed, except a lower K+ level was detected in female rats in the high dose group[14-16]. In an independent investigation, Prado et al. demonstrated that acute and subchronic toxicities of mangiferin (p.o.) are low[16]. A detailed anti-mutagenic investigation was conducted by Gold-Smith et al. [17], which affirms the non-mutagenic potential of magniferin.

Antioxidant Benefits
Structurally mangiferin has four hydroxyl groups and exhibits potent free radicals and antioxidant activities by scavenging noxious free radicals[18-22]. Saha et al.[23] postulated that the C-glucosyl linkage and hydroxyl groups in mangiferin contribute significantly to its free radical-scavenging activity. Antioxidant potential of mangiferin is remarkably enhanced in the pro-inflammatory and inflammatory conditions, including infection and diabetic states[18-20]. DPPH assay also demonstrated that mangiferin has potent antioxidant activity and it is comparable to rutin[19]. Hydrogen peroxide-induced lipid peroxidation in human peripheral blood lymphocytes was dramatically reduced in a dose-dependent manner. It is a potent iron chelator and protects against noxious hydroxyl radicals and UV radiation[19,20].Pardo-Andreu et al. demonstrated that mangiferin counterbalances the iron-induced oxygen free radical formation, Fe2+ accumulation and iron-induced toxicity[24]. Fe2+ Citrate-induced lipid peroxidation in rat liver mitochondria was protected by the iron complexing ability of mangiferin[21,24].

In anindependent investigation, the protective ability of mangiferinwas assessed against H2O2 –induced oxidative injury and apoptosis in osteoblast-like cultured MC3T3-E1 cells. Mangiferin protectedthese cultured cells against oxidative injury through modulation of ERK5/Nrf2 signaling. Thus, it may be serving as a potential therapy in osteoporosis[25].
In vivo hepatoprotective ability of mangiferin against carbon tetrachloride-induced hepatic injury was demonstrated by Pokorski et al.[11,12]. Arsenic-induced oxidative stress in the hepatic tissues and liver dysfunction was also dramatically protected by mangiferin in another independent study[26].

Anti-inflammatory Benefits
The anti-inflammatory potential of magniferin has been demonstrated in both hepatoprotection[27] and cardioprotection[28,29] models.Lipopolysaccharide (LPS) and D-galactosamine-induced acute liver injury and inflammationwas significantly protected by mangiferin[30]. Hepatic lipid peroxidation and oxidative stress were significantly reduced as well as the levels of serum ALT, AST, IL-1β, TNF-α, MCP-1, and RANTES (regulated on activation, normal T cell expressed and secreted) were dramatically reduced[30]. Mangiferin up-regulated the expression of Nrf2 and HO-1 in a dose-dependent manner.Mangiferinalso inhibited LPS and D-galactosamine-induced hepatic NLRP3, ASC, caspase-1, IL-1β and TNF-α expression. Overall, the researchers concluded thatmangiferinprotected against hepatic injury and inflammation by activating the Nrf2 pathway and regulating NLRP3 inflammasome activation[30].Mangiferin demonstrated the protective abilities of mangiferinagainst DOX-induced cardiac inflammation, cardiotoxicity and apoptosis in rats via down-regulation of proapoptotic and proinflammatory gene expressions, upregulation of SERCA2a gene expression, and normalization of cytosolic calcium level[28]. Anethanol extract of Mangiferaindica L. leaf enriched in mangiferindemonstrated the antioxidant, anti-inflammatory and cardioprotective efficacy[31].

Pardo-Andreu GL et al. demonstrated the anti-inflammatory potential of magniferin in both in vitro and in vivo models. Mangiferin dose-dependently inhibited inflammatory cytokines, TNFα, NO and NF-kb[19-21,24]. Sahaet al. hypothesized that C-glucosyl linkage and hydroxyl groups in mangiferin contribute to its free radical-scavenging activity, and exhibited that mangiferin exerts its anti-inflammatory benefits by modulating various transcription factors including NF-κB, Nrf-2, TNF-α and COX-2[23,26].Mangiferinalso protected against renal ischemia-reperfusion injury by inhibiting inflammation, oxidative stress and inducing adenosine production in a mice model[32]. Mangiferin improved kidney function, increased CD73 expression in kidney’s suffering from ischemia-reperfusion injury, adenosine production, as well as inhibited pro-inflammatory responses and tubular apoptosis[32].

Pulmonary inflammation model was investigated by Gong et al. and exhibited that mangiferin can attenuate cecal ligation and puncture-induced mortality and acute lung injury as demonstrated by reduced systemic and pulmonary inflammatory responses[33]. Mangiferin also inhibited sepsis-activated MAPKand NFsignaling, demonstrating its inhibitionability against inflammatory mediators in sepsis-induced acute lung injury. Mangiferinwas demonstrated to upregulate HO-1 in the pulmonary tissues of septic mice in a dose-dependent manner[33]. The protective ability of magniferin against 2,4,6-trinitrobenzensulfonic acid (TNBS)-induced colitis in rodents was demonstrated by Szandruk et al.Mangiferin dramatically reduced the macro- and microscopic damage, as well as reduced MDA level in the colon[34]. Furthermore, TNF-α and IL-17 levels were reduced, while enhancing the SOD activity in the colon tissues. Thus, mangiferin significantly protected against TNBS-induced inflammation and colitis in rats by potentiating anti-inflammatory and antioxidant activity[34].

Anti-Diabetic Therapy
Potential anti-diabetic therapy of mangiferin has been demonstrated by several investigators[35]. Mangiferin demonstrated a pro-hypoglycemic role by regulating glucose metabolism and insulin resistance. It also lowers cholesterol synthesis and inhibits the expression of tumor necrosis factor (TNFa) and nitric oxide synthase[35].

Mangiferin treatment over a period of 8 weeks significantly lowered plasma glucose and triglyceride levels in diabetes prone db/db mice[36]. Mangiferin also increased pancreatic beta cell mass and uptake of glucose and insulin uptake with increased phosphorylation of AMP activated protein kinase (AMPK)[36]. Chronic treatment with mangiferin prevented renal fibrosis as well as decreased collagen IV in diabetic rats[37]. Furthermore, mangiferin treatment can reduce IL-1β in the serum and kidneys of diabetic rats. Mangiferin treatment 15, 30 and 60 mg/kg body weight treatment for 9 weeks improved chronic renal problems in diabetic rats and reduced kidney weight, as well as normalized blood urea nitrogen[37]. In another independent study, mangiferin significantly reduced diabetes-induced lipid peroxidation (TBARS) level to a healthy level[38]. In addition, Pokorski et al. also exhibited its potent in vivo hepatoprotectiveability[38,39]. In another independent study, mangiferin exerted anti-diabetic efficacy in streptozotocin-induced diabetic rats[40].

As we all realize that diabetes treatment causes both health and economic burden on society, thus, it will be unique if mangiferin can exhibit a novel therapeutic intervention. Plant-based diet has been demonstrated to effectively reduce high blood sugar level and eliminating the regular use of anti-diabetic medication and insulin, which will eliminate the risk of side effects of medicines. A recent clinical investigation by Dr. Roychowdhury exhibited 84% of patients reported controlled blood glucose level and reduced glycemic index by using raw mango fruits and the subjects were strictly on vegetarian diet[41]. These researchers indicated that consumption of hot water extract of mango leaves and mango leaf powder are very beneficial for diabetics.

Obese, diabetic and pre-diabetic subjects were also benefitted by using mango leaf extract. Research demonstrated that other components in mango including quercetin and mangiferin derivatives can trigger the cellular components, which are the target of anti-diabetic drugs[41].

Gastrointestinal Motility and Health
Mangiferin transits through the gastrointestinal tract, metabolized into different phenolic acid derivativesincluding 3,4-dihydroxybenzoic acid, 3,4-dihydroxy-phenylacetic acid, 2,4,6-trihydroxybenzoic acid, 3,4,5-trihydroxybenzoic acidand the mangiferinaglycone (1,3,6,7-tetrahydroxyxanthen-9-one, also known as norathyriol),by intestinal microflora in the colon and exerts the medicinal benefits[42,43]. Research studies have demonstrated that mangiferin attenuates intestinal inflammation and impaired gastrointestinal motility, and ultimately facilitates gastrointestinal transit and demonstrated anti-ulcerogenic potential[44]. It was emphasized that mangiferin remarkably suppressed myeloperoxidase activity, nitrate/nitrite levels, cytokines, adhesion molecules, and pro-inflammatory mediators in the ileum. Based on these extensive mechanistic investigations, it was emphasized that mangiferin may serve as an ideal therapeutic intervention for human inflammatory bowel disorders[45,46]. Another independent study demonstrated that mangiferin exerted significant gastroprotection in rodents. Mangiferin also exerted antioxidative and gastroprotective activity against ethanol and endomethacin-induced gastric lesion, ulcer score and depletion of gastric mucosal non-protein sulfhydryl content in mice[47].

Kakino et al. exhibited that mangiferin exerted the laxative effect via acetylcholine receptors, which was demonstrated in a mouse model of constipation[48], and enhances gastrointestinal regularity. In a mouse model of colitis and inflammatory bowel disease (IBD), Somani et al exhibited that mangiferin reduced colonic injury by reducing oxidative stress and inflammation by modulating TNF-α and MMP-9, and thus, Somani et al. [49] concluded that mangiferin may have potential to treat IBD.

Sanugul et al. [50]reported that a specific intestinal bacterium is involved in the metabolism of mangiferin, which is mediated through the production of a novel and inducible C-glucosyl-cleaving enzyme.Mahmoud-Awny et al.[51] demonstrated that mangiferin exerted its gastroprotective ability in a rat gastric ulcer model partly via inducing the expression of Nrf2, HO-1 and PPAR-γ along with downregulating NF-κb, while anti-inflammatory benefits were demonstrated by reducing serum IL-1β and sE-selectin levels. Mangiferin enhanced the total antioxidant capacity and glutathione level, reduced the malondialdehyde level, and attributed anti-apoptotic benefits by escalating Bcl-2 level and reducing caspase-3 in a dose-dependent manner[51].

Most interestinglymangiferin was demonstrated to effectively eradicate Helicobacter pylori, the most noxious bacteria responsible for chronic gastrointestinal inflammation, ulcer and gastric cancer[52,53].Mangiferineffectively eradicatedH. pylori and remarkably inhibited inflammatory markers NF-κΒ subunit p65, IL-1β, IL-8, and TNFα[52,53], downregulated inflammatory enzymes COX-2 and iNOS, as well as deactivated NF-p65 by blocking the inflammatory response. Thus, a mangiferin-enriched dietary supplement will be a good choice to serve as a novel gastroprotective supplement.


Mango leaves, barks, flowers, fruits and pulp are unique resources of mangiferin and structurally diverse antioxidants including vitamins A, B6, E and C, pectin, flavonoids, beta-cryptoxanthin, omega-3 and omega-6 fatty acids, fibers, micronutrients and minerals including copper, which provides a soothing taste and smell and diverse pharmacological and therapeutic benefits. Moreover, mango is enriched in mangiferin, a natural polyphenol of C-glycosylxanthone structural moiety, and its derivatives. Both mango and mango leaf extract can improve insulin production and sensitivity, stabilizing blood sugar level and normalizes glycemic in pre-diabetics and diabetics.The tender leaves of mango tree are enriched in anthocyanidins, which help in treating pre-diabetic subjects, and the dried powdered leaves helps to treat diabetic angiopathy and diabetic retinopathy. Overall, these are safe and novel antioxidant, anti-inflammatory, anti-diabetic, anti-ulcerogenic, nephroprotectant, gastrointestinal health and bowel movement.

Figure 1. Chemical structure of mangiferin.


1. United Nations Conference of Trade and Development. Mango: An Infocomm Commodity Profile UNCTAD Trust Fund on Market Information on Agricultural Commodities. UNCTAD, New York and Geneva 2016.
2. Imran M, Arshad MS, Butt MS.Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids Health Dis 2017; 16:84.
3. Shah KA, Patel MB, Patel RJ.MangiferaIndica (Mango). Pharmacogn Rev 2010; 4: 42–48.
4. Acevedo LM, Raya AI, Martinez-Moreno JM.Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats. PLoS One 2017; 12(3): e0173028.
5. Okwu DE, Ezenagu V. Evaluation of the phytochemical composition of mango (Magniferraindica Linn.) stem, bark and leaves. Int J ChemSci 2008; 6: 705-716.
6. Glehill D. West African trees, Longman, Hong Kong, (1972) pp.67.
7. Oliver-Baver B. Medicinal plants in tropical West Africa. Cambridge University Press, London (1986) pp 51.
8. Dzamic AM, Marin PD, Gbolade AA, Ristic MS. Chemical composition of Magniferaindica essential oil from Nigeria. J Essen Oil Res 2010; 22: 123-125
9. Joubert E, Otto F, Gruner S, Weinreich B. Reversed-phase HPLC determination of mangiferin, isomangiferin and hesperidin in Cyclopia and the effect of harvesting date on the phenolic composition of C. genistoides. Eur Food Res Technol 2003; 216: 270–273
10. Zhou T, Zhu Z, Wang C, Fan G, Peng J, Chai Y, Wu Y. On-line purity monitoring in high-speed counter-current chromatography: Application of HSCCC-HPLC-DAD for the preparation of 5-HMF, neomangiferin and mangiferin from Anemarrhenaasphodeloides Bunge. J. Pharmaceut. Biomed. Anal. 2007; doi:10.1016/j.jpba.2007.01.050.
11. Ramirez JE, Zambrano R, Sepulveda B, Simirgiotis MJ. Antioxidant Properties and Hyphenated HPLC-PDA-MS Profiling of Chilean Pica Mango Fruits (MangiferaindicaL. Cv. piqueño). Molecules 2014, 19, 438-458; doi:10.3390/molecules19010438.
12. Acosta J, Sevilla I, Salomon S, Nuevas L, Romero A, Amaro D. Determination of magniferin solubility in solvents used in the biopharmaceutical university. J. Pharm. Pharmacogn. Res. 2016; 4(2): 49-53.
13. Zhao Y, Wang W, Wu X, Ma X, Qu R, Chen X, Liu C, Liu Y, Wang X, Yan P, Zhang H, Pan J, Li W. Mangiferin antagonizes TNF-α-mediated inflammatory reaction and protects against dermatitis in a mice model. Int. Immunopharmacol. 2017; 45: 174-179.
14. Mango and mango leaves, Mangiferaindica L, Health Benefits and Interesting Facts. Mango Leaves Extract. (accessed Mar 25, 2018)
15. Zhang Y, Li J, Wu Z, Liu E, Shi P, Han L, Guo L, Gao X, Wang L. Acute and long-term toxicity of mango leaves extract in mice and rats. Evidence-Based Complimentary and Alternative Medicine. 2014, Article ID 691574
16. Y Prado, N Merino, J Acosta, JA Herrera, Y Luque, I Hernández, E Prado, G Garrido, R Delgado, I Rodeiro. Acute and 28-day subchronic toxicity studies of mangiferin, a glucosylxanthone isolated from Mangiferaindica L. stem bark.J Pharm Pharmacog Res 2015; 3: 13-23.
17. Gold-Smith F, Fernandez A, Bishop K. Mangiferin and cancer: Mechanisms of action. Nutrients 2016 Jun 28;8(7). pii: E396. doi: 10.3390/nu8070396.
18. Dar A, Faizi S, Naqvi S, Roome T, Zikr-ur-Rehman S, Ali M, Firdous S, Moin ST. Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship. Biol Pharm Bull 2005; 28: 596-600
19. Pardo-Andreu GL, Delgado R, Nunez-Selles AJ, Vercesi AE. Dual mechanism of mangiferin protection against iron-induced damage to 2-deoxyribose and ascorbate oxidation. Pharmacol Res 2006: 53: 253-260.
20. Pardo-Andreu GL, Sánchez-Baldoquín C, Avila-González R, Yamamoto ET, Revilla A, Uyemura SA, Naal Z, Delgado R, Curti C. Interaction of Vimang (Mangiferaindica L. extract) with Fe(III) improves its antioxidant and cytoprotecting activity. Pharmacol Res 2006: 54: 389-395.
21. Pardo-Andreu GL, Sánchez-Baldoquín C, Avila-González R, Delgado R, Naal Z, Curti C. Fe(III) improves antioxidant and cytoprotecting activities of mangiferin. Eur J Pharmacol 2006; 547: 31-36.
22. Jain PK, Kharya M, Gajbhjye A. Pharmacological evaluation of mangiferinherbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage. Drug DevInd Pharm 2013; 39:1840-1850.
23. Saha S, Sadhukhan P, Sil PC. Mangiferin: A xanthonoid with multipotent anti-inflammatory potential. Biofactors 2016; 42: 459-474.
24. Pardo-Andreu GL, Delgado R, Núñez-Sellés AJ, Vercesi AE. Mangiferaindica L. extract (Vimang) inhibits 2-deoxyribose damage induced by Fe(III) plus ascorbate. Phytother Res 2006; 20:120-124.
25. Pan CW, Pan ZZ, Hu JJ, Chen WL, Zhou GY, Lin W, Jin LX, Xu CL.Mangiferinalleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Eur J Pharmacol 2016; 770: 85-91.
26. Saha S, Rashid K, Sadhukhan P, Agarwal N, Sil PC, Attenuative role of mangiferin in oxidative stress-mediated liver dysfunction in arsenic-intoxicated murines. Biofactors 2016; 42: 515-532.
27. Jain PK, Kharya M, Gajbhjye A. Pharmacological evaluation of mangiferinherbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage. Drug DevInd Pharm 2013; 39:1840-1850.
28. Agustini FD, Arozal W, Louisa M, Siswanto S, Soetikno V, Nafrialdi N, Suyatna F. Cardioprotection mechanism of mangiferin on doxorubicin-induced rats: Focus on intracellular calcium regulation. Pharm Bull 2016; 54: 1289-1297.
29. Suchal K, Malik S, Gamad N, Malhotra RK, Goyal SN, Ojha S, Kumari S, Bhatia J, Arya DS. Mangiferin protect myocardial insults through modulation of MAPH/TGF-pathways. Eur J.Pharmacol. 2016;776: 34-43.
30. Pan CW, Pan ZZ, Hu JJ, Chen WL, Zhou GY, Lin W, Jin LX, Xu CL. Mangiferinalleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Eur J Pharmacol 2016; 770: 85-91.
31. Bhatt L, Joshi V, Mangiferaindica L. Leaf extract alleveviates doxorubicin induced stress. J.Intercul.Ethnopharmacol.2017; 6:284-289.
32. Wang B, Wan J, Gong X, Kuang G, Cheng X, Min S. Mangiferin attenuates renal ischemia-reperfusion injury by inhibiting inflammation and inducing adenosine production. Int. Immunopharmacol 2015; 25: 148-15
33. Gong X, Zhang L, Jiang R, Ye M, Yin X, Wan J. Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1. J. Nutr. Biochem 2013; 24: 1173-1181.
34. Szandruk M, Merwid-Lad A, Szelag A. The impact of mangiferin from Belamcandachinensis on experimental colitis in rats. Inflammopharmacology 2017 Mar 24. PMID: 28337639 DOI: 10.1007/s10787-017-0337-0.
35. Miura T, Ichiki H, Hashimoto I, Iwamoto N, Kato M, Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine2001; 8: 85-87.
36. Han J, Yi J, liang F, et al. X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduced hyperglycemia and obesity in db/db mice. Mol Cell Endocrinol. 2015; 405: 63-73.
37. Zhu X, Cheng YQ, Du L, et al. Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats. PhytotherRes. 2015; 29: 295-302.
38. Pokorski M. Mangiferin – A Nutraceutical with Clinical Implications. Vitam Miner. 2013; 2:e122.
39. Pokorski M, Rekawek A, Zasada I. Antioxidation and and the hypoxic ventilatory response. AdvExp Med Biol. 2012; 758: 373-380.
40. Muruganandan S, Srinivasan K, Gupta S, et al. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol. 2005; 97: 497-501.
41. Roy Chowdhury B. Diabetes reversal by plant-based diet. J Metabolic Synd. 2017; 6:4
42. Huang H, Tan Z, Deng J, et al. Metabolism of mangiferin by human intestinal bacteria in vitro. ZhongguoZhong Yao ZaShiI. 2011; 36: 443-445
43. Bock C, Ternes W. The phenolic acids from bacterial degradation of the mangiferinaglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopiagenistoides (honeybush tea). Nutr Res. 2010; 30: 348-357.
44. Severi JA,Lima ZP, Kushima H, et al. Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangiferaindica L.). Molecules. 2009; 14: 1098-1110.
45. Morais TC, Lopes SC, Carvalho KMMB, et al. Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism. World J Gastroenterol. 2012; 18: 3207- 3214.
46. Morais TC, Arruda BR, de Sousa Mogalhaes H. Mangiferin ameliorates the intestinal inflammatory response and the impaired gastrointestinal motility in mouse model of postoperative ileus. NaunynSchmiedebergs Arch Pharmacol. 2015; 388: 531-538.
47. Carvalho AC, Guedes MM, de Souza AL. Gastroprotective effect of mangiferin, a xanthonoid from Mangiferaindica, against gastric injury induced by ethanol and indomethacin in rodents. Planta Med. 2007; 73:1372-1376.
48. Kakino M, Izuta H, Ito T, et al. Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. BiosciBiotechnolBiochem. 2010; 74: 1550-1555.
49. Somani S, Zambad S, Modi K. Mangiferin attenuates DSS colitis in mice: Molecular docking and in vivo approach. ChemBiol Interact. 2016; 253: 18-26.
50. Sanugul K, Akao T, Li Y, et al. Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. Biol Pharm Bull. 2005; 28: 1672-1678.
51. Mahmoud-Awny M, Attia AS, Abd-Ellah MF, et al. Mangiferin mitigates gastric ulcer in ischemia/reperfused rats: Involvement of PPAR-γ, NF- κB and Nrf2/HO-1 signaling pathways. PLoS One. 2015. 10(7):e0132497.
52. Zhang QJ, Yue L. Inhibitory activity of mangiferin on Helicobacter pylori-induced inflammation in human gastric carcinoma AGS cells. Afr J Tradit Compliment Altern Med. 2016; 14: 263-271.
53. Castillo-Juarez I, Gonzalez V, Jaime-Aguilar H, et al. Anti-Helicobacter pylori activity of plants used in Mexican traditional medicine for gastrointestinal disorders. J Ethnopharmacol. 2009; 122: 402-405.


Jpn J Med 2018,1:2
2018; 1(2):

To cite this article: Swaroop A, Bagchi M, Moriyama H,et al.Health Benefits of Mango (Mangiferaindica L) and Mangiferin Japan Journal of Medicine. 2018; 1:2.
© 2018 Swaroop A, et al.